Injectable codeine is available for subcutaneous or intramuscular injection only; intravenous injection is contraindicated, as this may lead to nonimmune mast-cell degranulation and ensuing anaphylactoid reaction. Codeine suppositories may also be marketed in a few international locations. In Ireland, new regulations arrived into impact on one August 2010[ninety] concerning codeine, https://codeingil.com/