Abstract Background Hi-C data have been widely used to reconstruct chromosomal three-dimensional (3D) structures. One of the key limitations of Hi-C is the unclear relationship between spatial distance and the number of Hi-C contacts. Many methods used a fixed parameter when converting the number of Hi-C contacts to wish distances. https://www.jmannino.com/amazing-price-Handlebar-for-Motovox-MBX10-and-MBX11-Mini-Bikes-amazing-deal/