Acute renal failure (ARF) is a frequent complication of Gram-negative sepsis. with a high risk of mortality. Lipopolysaccharide (LPS)-induced ARF is associated with hemodynamic changes that are strongly influenced by the overproduction of nitric oxide (NO) through the cytokine-mediated up-regulation of inducible NO synthase. LPS-induced reductions in systemic vascular resistance parad... https://www.hacklinkci.com/